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Semaglutide

GLP-1 Weight Loss Medication

14.9%
avg. weight loss
68 wks
clinical trial
$148/mo
all dosages

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Clinical Evidence

What the Research Shows

STEP 1 Trial (2021) · 1,961 participants · 68 weeks

Semaglutide (2.4 mg/week)14.9%
Placebo2.4%

Average body weight reduction at 68 weeks. Bars scaled to 25% max. Individual results vary.

Ozempic (brand-name semaglutide) demonstrated statistically significant, clinically meaningful weight loss vs. placebo in the STEP 1 trial. Participants followed a reduced-calorie diet and increased physical activity alongside treatment.

Important: The clinical trial data above refers to Ozempic, the FDA-approved brand-name semaglutide. Compounded semaglutide has not been studied in clinical trials and has not been approved by the U.S. Food and Drug Administration (FDA) for safety or efficacy. Compounded medications are prepared by licensed pharmacies under FDA oversight of pharmacy practices, but the compounded formulation itself is not FDA-approved.

Mechanism

How Semaglutide Works

GLP-1 Receptor Agonist

Mimics GLP-1, a hormone naturally released after eating, signaling fullness to the brain and reducing appetite

Slows gastric emptying so you feel satisfied longer after meals — reducing overall caloric intake

Acts on hunger centers in the hypothalamus to reduce food cravings between meals

Improves insulin sensitivity and helps regulate blood sugar, supporting metabolic health beyond weight loss

These statements have not been reviewed by the FDA.

Titration

Dosing Schedule

Your clinician may adjust timing based on your individual response and tolerability.

1
Weeks 1–40.25 mg/week

Starter dose — lets your body adjust with minimal GI side effects

2
Weeks 5–80.5 mg/week

Building tolerance; early appetite-suppressing effects begin

3
Weeks 9–121.0 mg/week

Active therapeutic range — most patients notice meaningful changes

4
Weeks 13–161.7 mg/week

Enhanced efficacy phase; continued weight loss acceleration

5
Week 17+2.4 mg/week

Full dose — maximum weight loss benefit sustained

All dosages included in your monthly price. You will not be charged more as your dose increases through the titration schedule.

Microdosing Protocol

Flat Dose. Different Goals.

The standard titration schedule is designed to maximise weight loss in patients following a reduced-calorie diet. The microdosing protocol is a separate application — a single low dose held flat throughout treatment, calibrated for active individuals who want metabolic and recovery benefits without significant appetite suppression.

Flat weekly dose

0.125 mg/week

Maintained from week 1 — no titration upward
Clinician may adjust based on your response
$99/mo · all supplies included
Start microdosing intake →

Dose comparison

Standard (maintenance)2.4 mg/week
Microdose (flat)0.125 mg/week

Relative dose only. Not to clinical scale.

  • Roughly 10% of the standard maintenance dose — activates GLP-1 receptors without full appetite suppression
  • Designed for athletes and active individuals who need to eat enough to fuel training
  • May support reduced systemic inflammation and faster recovery between sessions
  • Smoother blood sugar regulation without the energy crashes common at higher doses
Compare

Semaglutide vs. Tirzepatide

Semaglutide
← you are here
Tirzepatide
Mechanism
GLP-1 Receptor Agonist
Dual GIP + GLP-1 agonist
Avg. Weight Loss
14.9%
20.9%
Max Dose
2.4 mg/week
15 mg/week
Injection
Once weekly
Once weekly
Terna Price
$148/mo
$266/mo
Best For
First-line GLP-1 therapy with a deep evidence base
Maximum weight loss, dual-hormone mechanism

View full Tirzepatide page →

Pricing

All dosages. One price.

You pay the same from your first starter dose through maintenance. No surprise charges as your dose increases.

$148/mo
  • Compounded medication — all titration doses
  • Licensed physician review
  • Free home delivery
  • Unlimited provider messaging
  • On-demand prescription refills

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