← All MedicationsDual GIP + GLP-1 Agonist

Tirzepatide

Dual GIP/GLP-1 Receptor Agonist

20.9%
avg. weight loss
72 wks
clinical trial
$266/mo
all dosages

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Clinical Evidence

What the Research Shows

SURMOUNT-1 Trial (2022) · 2,539 participants · 72 weeks

Tirzepatide (15 mg/week)20.9%
Placebo3.1%

Average body weight reduction at 72 weeks. Bars scaled to 25% max. Individual results vary.

Zepbound (brand-name tirzepatide) demonstrated statistically significant, clinically meaningful weight loss vs. placebo in the SURMOUNT-1 trial. Participants followed a reduced-calorie diet and increased physical activity alongside treatment.

Important: The clinical trial data above refers to Zepbound, the FDA-approved brand-name tirzepatide. Compounded tirzepatide has not been studied in clinical trials and has not been approved by the U.S. Food and Drug Administration (FDA) for safety or efficacy. Compounded medications are prepared by licensed pharmacies under FDA oversight of pharmacy practices, but the compounded formulation itself is not FDA-approved.

Mechanism

How Tirzepatide Works

Dual GIP + GLP-1 Receptor Agonist

Simultaneously activates both GIP and GLP-1 receptors — a dual-action mechanism not possible with GLP-1 agonists alone

GIP receptor activation enhances fat metabolism and complements GLP-1's appetite-suppressing effects for greater total impact

Slows gastric emptying and amplifies satiety signals, reducing caloric intake through two distinct hormonal pathways

Head-to-head trial data shows superior weight loss compared to semaglutide at maximum doses

These statements have not been reviewed by the FDA.

Titration

Dosing Schedule

Your clinician may adjust timing based on your individual response and tolerability.

1
Weeks 1–42.5 mg/week

Starter dose — gentle introduction to minimize GI side effects

2
Weeks 5–85 mg/week

Tolerance-building phase; appetite effects begin

3
Weeks 9–127.5 mg/week

Therapeutic range — meaningful weight loss typically begins here

4
Weeks 13–1610 mg/week

Enhanced efficacy phase; most patients see significant progress

5
Weeks 17–2012.5 mg/week

Advanced efficacy — approaching peak dose

6
Week 21+15 mg/week

Maximum dose — peak weight loss outcomes sustained

All dosages included in your monthly price. You will not be charged more as your dose increases through the titration schedule.

Microdosing Protocol

Flat Dose. Different Goals.

The standard titration schedule is designed to maximise weight loss in patients following a reduced-calorie diet. The microdosing protocol is a separate application — a single low dose held flat throughout treatment, calibrated for active individuals who want metabolic and recovery benefits without significant appetite suppression.

Flat weekly dose

1.25 mg/week

Maintained from week 1 — no titration upward
Clinician may adjust based on your response
$157/mo · all supplies included
Start microdosing intake →

Dose comparison

Standard (maintenance)15 mg/week
Microdose (flat)1.25 mg/week

Relative dose only. Not to clinical scale.

  • 1/2 the starter dose held flat — activates both GIP and GLP-1 receptors at a fraction of the weight-loss dose
  • Dual-receptor activity at low doses may offer enhanced metabolic and anti-inflammatory effects vs. GLP-1 alone
  • Appetite is largely preserved — critical for athletes who must fuel training loads adequately
  • Shorter GI adjustment period than the full titration protocol; most patients tolerate it well from week one
Compare

Semaglutide vs. Tirzepatide

Semaglutide
Tirzepatide
← you are here
Mechanism
GLP-1 receptor agonist
Dual GIP + GLP-1 Receptor Agonist
Avg. Weight Loss
14.9%
20.9%
Max Dose
2.4 mg/week
15 mg/week
Injection
Once weekly
Once weekly
Terna Price
$148/mo
$266/mo
Best For
First-line GLP-1 therapy with a deep evidence base
Maximum weight loss outcomes, dual-hormone mechanism

View full Semaglutide page →

Pricing

All dosages. One price.

You pay the same from your first starter dose through maintenance. No surprise charges as your dose increases.

$266/mo
  • Compounded medication — all titration doses
  • Licensed physician review
  • Free home delivery
  • Unlimited provider messaging
  • On-demand prescription refills

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